2nv7

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{{STRUCTURE_2nv7| PDB=2nv7 | SCENE= }}
{{STRUCTURE_2nv7| PDB=2nv7 | SCENE= }}
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'''Crystal Structure of Estrogen Receptor Beta Complexed with WAY-555'''
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===Crystal Structure of Estrogen Receptor Beta Complexed with WAY-555===
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==Overview==
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A series of 4'-hydroxyphenyl-aryl-carbaldehyde oximes (5b) was prepared and found to have high affinity (4nM) and modest selectivity (39-fold) for estrogen receptor-beta (ERbeta). Substitution of one of the core rings of the scaffold based around these novel ligands further expanded our knowledge in the quest toward achieving high affinity and selectivity for ERbeta. An X-ray co-crystal of structure 11 revealed that the oxime moiety was mimicking the C-ring of genistein, as previously predicted by SAR and docking studies.
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(as it appears on PubMed at http://www.pubmed.gov), where 17188490 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17188490}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:56:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:04:43 2008''

Revision as of 11:04, 29 July 2008

Image:2nv7.png

Template:STRUCTURE 2nv7

Crystal Structure of Estrogen Receptor Beta Complexed with WAY-555

Template:ABSTRACT PUBMED 17188490

About this Structure

2NV7 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

ERbeta ligands. Part 5: synthesis and structure-activity relationships of a series of 4'-hydroxyphenyl-aryl-carbaldehyde oxime derivatives., Mewshaw RE, Bowen SM, Harris HA, Xu ZB, Manas ES, Cohn ST, Bioorg Med Chem Lett. 2007 Feb 15;17(4):902-6. Epub 2006 Dec 1. PMID:17188490

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