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2rmj

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[[Image:2rmj.jpg|left|200px]]
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{{STRUCTURE_2rmj| PDB=2rmj | SCENE= }}
{{STRUCTURE_2rmj| PDB=2rmj | SCENE= }}
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'''Solution structure of RIG-I C-terminal domain'''
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===Solution structure of RIG-I C-terminal domain===
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==Overview==
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A DExD/H protein, RIG-I, is critical in innate antiviral responses by sensing viral RNA. Here we show that RIG-I recognizes two distinct viral RNA patterns: double-stranded (ds) and 5'ppp single-stranded (ss) RNA. The binding of RIG-I with dsRNA or 5'ppp ssRNA in the presence of ATP produces a common structure, as suggested by protease digestion. Further analyses demonstrated that the C-terminal domain of RIG-I (CTD) recognizes these RNA patterns and CTD coincides with the autorepression domain. Structural analysis of CTD by NMR spectroscopy in conjunction with mutagenesis revealed that the basic surface of CTD with a characteristic cleft interacts with RIG-I ligands. Our results suggest that the bipartite structure of CTD regulates RIG-I on encountering viral RNA patterns.
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(as it appears on PubMed at http://www.pubmed.gov), where 18242112 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18242112}}
==About this Structure==
==About this Structure==
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2RMJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMJ OCA].
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2RMJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMJ OCA].
==Reference==
==Reference==
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[[Category: Rna-binding]]
[[Category: Rna-binding]]
[[Category: Ubl conjugation]]
[[Category: Ubl conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:10:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:11:27 2008''

Revision as of 11:11, 29 July 2008

Image:2rmj.png

Template:STRUCTURE 2rmj

Solution structure of RIG-I C-terminal domain

Template:ABSTRACT PUBMED 18242112

About this Structure

2RMJ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses., Takahasi K, Yoneyama M, Nishihori T, Hirai R, Kumeta H, Narita R, Gale M Jr, Inagaki F, Fujita T, Mol Cell. 2008 Feb 29;29(4):428-40. Epub 2008 Jan 31. PMID:18242112

Page seeded by OCA on Tue Jul 29 14:11:27 2008

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