2bkj

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{{Seed}}
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{{STRUCTURE_2bkj| PDB=2bkj | SCENE= }}
{{STRUCTURE_2bkj| PDB=2bkj | SCENE= }}
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'''NADPH:FMN OXIDOREDUCTASE FROM VIBRIO HARVEYI COMPLEXED WITH NAD+'''
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===NADPH:FMN OXIDOREDUCTASE FROM VIBRIO HARVEYI COMPLEXED WITH NAD+===
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==Overview==
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The 2.1 A resolution crystal structure of flavin reductase P with the inhibitor nicotinamide adenine dinucleotide (NAD) bound in the active site has been determined. NAD adopts a novel, folded conformation in which the nicotinamide and adenine rings stack in parallel with an inter-ring distance of 3.6 A. The pyrophosphate binds next to the flavin cofactor isoalloxazine, while the stacked nicotinamide/adenine moiety faces away from the flavin. The observed NAD conformation is quite different from the extended conformations observed in other enzyme/NAD(P) structures; however, it resembles the conformation proposed for NAD in solution. The flavin reductase P/NAD structure provides new information about the conformational diversity of NAD, which is important for understanding catalysis. This structure offers the first crystallographic evidence of a folded NAD with ring stacking, and it is the first enzyme structure containing an FMN cofactor interacting with NAD(P). Analysis of the structure suggests a possible dynamic mechanism underlying NADPH substrate specificity and product release that involves unfolding and folding of NADP(H).
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The line below this paragraph, {{ABSTRACT_PUBMED_10493573}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10493573 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10493573}}
==About this Structure==
==About this Structure==
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[[Category: Frp]]
[[Category: Frp]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:25:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:16:26 2008''

Revision as of 11:16, 29 July 2008

Image:2bkj.png

Template:STRUCTURE 2bkj

NADPH:FMN OXIDOREDUCTASE FROM VIBRIO HARVEYI COMPLEXED WITH NAD+

Template:ABSTRACT PUBMED 10493573

About this Structure

2BKJ is a Single protein structure of sequence from Vibrio harveyi. Full crystallographic information is available from OCA.

Reference

Unusual folded conformation of nicotinamide adenine dinucleotide bound to flavin reductase P., Tanner JJ, Tu SC, Barbour LJ, Barnes CL, Krause KL, Protein Sci. 1999 Sep;8(9):1725-32. PMID:10493573

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