1xpx

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[[Image:1xpx.gif|left|200px]]
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{{Seed}}
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[[Image:1xpx.png|left|200px]]
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{{STRUCTURE_1xpx| PDB=1xpx | SCENE= }}
{{STRUCTURE_1xpx| PDB=1xpx | SCENE= }}
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'''Structural basis of prospero-DNA interaction; implications for transcription regulation in developing cells'''
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===Structural basis of prospero-DNA interaction; implications for transcription regulation in developing cells===
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==Overview==
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The crystal structure of a complex between the novel homeodomain of the neural transcription factor Prospero and DNA shows that the invariant residues Lys1290, Asn1294, and Asp1297 make specific contacts with the noncanonical DNA binding site. The overall structure includes the homeodomain and the adjacent Prospero domain and confirms that they act as a single structural unit, a Homeo-Prospero domain. The Prospero domain facilitates the proper alignment of the protein on the DNA. Knowledge of the structure reconciles two different DNA sequences that have been proposed as transcriptional targets for Prospero. As in the apo structure, the C terminus of the Prospero domain shields a short helix within the homeodomain that includes a nuclear export signal (NES). The structural results suggest that exposure of the NES is not coupled directly to DNA binding. We propose a DNA recognition mechanism specific to Prospero-type homeodomains in developing cells.
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The line below this paragraph, {{ABSTRACT_PUBMED_15837198}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15837198 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15837198}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structural basis of Prospero-DNA interaction: implications for transcription regulation in developing cells., Yousef MS, Matthews BW, Structure. 2005 Apr;13(4):601-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15837198 15837198]
Structural basis of Prospero-DNA interaction: implications for transcription regulation in developing cells., Yousef MS, Matthews BW, Structure. 2005 Apr;13(4):601-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15837198 15837198]
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Structure of the DNA binding region of prospero reveals a novel homeo-prospero domain., Ryter JM, Doe CQ, Matthews BW, Structure. 2002 Nov;10(11):1541-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12429095 12429095]
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Prospero]]
[[Category: Prospero]]
[[Category: Protein-dna binding]]
[[Category: Protein-dna binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:21:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:16:43 2008''

Revision as of 11:16, 29 July 2008

Image:1xpx.png

Template:STRUCTURE 1xpx

Structural basis of prospero-DNA interaction; implications for transcription regulation in developing cells

Template:ABSTRACT PUBMED 15837198

About this Structure

1XPX is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural basis of Prospero-DNA interaction: implications for transcription regulation in developing cells., Yousef MS, Matthews BW, Structure. 2005 Apr;13(4):601-7. PMID:15837198

Structure of the DNA binding region of prospero reveals a novel homeo-prospero domain., Ryter JM, Doe CQ, Matthews BW, Structure. 2002 Nov;10(11):1541-9. PMID:12429095

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