2q6t

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[[Image:2q6t.gif|left|200px]]
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{{STRUCTURE_2q6t| PDB=2q6t | SCENE= }}
{{STRUCTURE_2q6t| PDB=2q6t | SCENE= }}
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'''Crystal structure of the Thermus aquaticus DnaB monomer'''
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===Crystal structure of the Thermus aquaticus DnaB monomer===
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==Overview==
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The ring-shaped hexameric DnaB helicase unwinds duplex DNA at the replication fork of eubacteria. We have solved the crystal structure of the full-length Thermus aquaticus DnaB monomer, or possibly dimer, at 2.9 A resolution. DnaB is a highly flexible two domain protein. The C-terminal domain exhibits a RecA-like core fold and contains all the conserved sequence motifs that are characteristic of the DnaB helicase family. The N-terminal domain contains an additional helical hairpin that makes it larger than previously appreciated. Several DnaB mutations that modulate its interaction with primase are found in this hairpin. The similarity in the fold of the DnaB N-terminal domain with that of the C-terminal helicase-binding domain (HBD) of the DnaG primase also includes this hairpin. Comparison of hexameric homology models of DnaB with the structure of the papillomavirus E1 helicase suggests the two helicases may function through different mechanisms despite their sharing a common ancestor.
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(as it appears on PubMed at http://www.pubmed.gov), where 17606462 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17606462}}
==About this Structure==
==About this Structure==
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[[Category: Helicase]]
[[Category: Helicase]]
[[Category: Replication]]
[[Category: Replication]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:27:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:18:16 2008''

Revision as of 11:18, 29 July 2008

Image:2q6t.png

Template:STRUCTURE 2q6t

Crystal structure of the Thermus aquaticus DnaB monomer

Template:ABSTRACT PUBMED 17606462

About this Structure

2Q6T is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

The crystal structure of the Thermus aquaticus DnaB helicase monomer., Bailey S, Eliason WK, Steitz TA, Nucleic Acids Res. 2007;35(14):4728-36. Epub 2007 Jul 1. PMID:17606462

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