1myl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1myl.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1myl.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1myl| PDB=1myl | SCENE= }}
{{STRUCTURE_1myl| PDB=1myl | SCENE= }}
-
'''SUBSTITUTING HYDROPHOBIC RESIDUES FOR A BURIED SALT BRIDGE ENHANCES PROTEIN STABILITY BUT DOES NOT REDUCE CONFORMATIONAL SPECIFICITY'''
+
===SUBSTITUTING HYDROPHOBIC RESIDUES FOR A BURIED SALT BRIDGE ENHANCES PROTEIN STABILITY BUT DOES NOT REDUCE CONFORMATIONAL SPECIFICITY===
-
==Overview==
+
<!--
-
The side chains of Arg 31, Glu 36 and Arg 40 in Arc repressor form a buried salt-bridge triad. The entire salt-bridge network can be replaced by hydrophobic residues in combinatorial randomization experiments resulting in active mutants that are significantly more stable than wild type. The crystal structure of one mutant reveals that the mutant side chains pack against each other in an otherwise wild-type fold. Thus, simple hydrophobic interactions provide more stabilizing energy than the buried salt bridge and confer comparable conformational specificity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_7749916}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 7749916 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_7749916}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Waldburger, C D.]]
[[Category: Waldburger, C D.]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:52:27 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:20:01 2008''

Revision as of 11:20, 29 July 2008

Image:1myl.png

Template:STRUCTURE 1myl

SUBSTITUTING HYDROPHOBIC RESIDUES FOR A BURIED SALT BRIDGE ENHANCES PROTEIN STABILITY BUT DOES NOT REDUCE CONFORMATIONAL SPECIFICITY

Template:ABSTRACT PUBMED 7749916

About this Structure

1MYL is a Single protein structure of sequence from Enterobacteria phage p22. Full crystallographic information is available from OCA.

Reference

Are buried salt bridges important for protein stability and conformational specificity?, Waldburger CD, Schildbach JF, Sauer RT, Nat Struct Biol. 1995 Feb;2(2):122-8. PMID:7749916

Page seeded by OCA on Tue Jul 29 14:20:01 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1myl"
Personal tools