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1zc8

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[[Image:1zc8.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1zc8| PDB=1zc8 | SCENE= }}
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'''Coordinates of tmRNA, SmpB, EF-Tu and h44 fitted into Cryo-EM map of the 70S ribosome and tmRNA complex'''
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===Coordinates of tmRNA, SmpB, EF-Tu and h44 fitted into Cryo-EM map of the 70S ribosome and tmRNA complex===
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==Overview==
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Bacterial ribosomes stalled on defective messenger RNAs (mRNAs) are rescued by tmRNA, an approximately 300-nucleotide-long molecule that functions as both transfer RNA (tRNA) and mRNA. Translation then switches from the defective message to a short open reading frame on tmRNA that tags the defective nascent peptide chain for degradation. However, the mechanism by which tmRNA can enter and move through the ribosome is unknown. We present a cryo-electron microscopy study at approximately 13 to 15 angstroms of the entry of tmRNA into the ribosome. The structure reveals how tmRNA could move through the ribosome despite its complicated topology and also suggests roles for proteins S1 and SmpB in the function of tmRNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 12677067 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12677067}}
==About this Structure==
==About this Structure==
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[[Category: Tmrna]]
[[Category: Tmrna]]
[[Category: Trans-translation]]
[[Category: Trans-translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:27:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:20:13 2008''

Revision as of 11:20, 29 July 2008

Image:1zc8.png

Template:STRUCTURE 1zc8

Coordinates of tmRNA, SmpB, EF-Tu and h44 fitted into Cryo-EM map of the 70S ribosome and tmRNA complex

Template:ABSTRACT PUBMED 12677067

About this Structure

Full crystallographic information is available from OCA.

Reference

Visualizing tmRNA entry into a stalled ribosome., Valle M, Gillet R, Kaur S, Henne A, Ramakrishnan V, Frank J, Science. 2003 Apr 4;300(5616):127-30. PMID:12677067

Page seeded by OCA on Tue Jul 29 14:20:13 2008

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