2bu3

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[[Image:2bu3.gif|left|200px]]
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{{STRUCTURE_2bu3| PDB=2bu3 | SCENE= }}
{{STRUCTURE_2bu3| PDB=2bu3 | SCENE= }}
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'''ACYL-ENZYME INTERMEDIATE BETWEEN ALR0975 AND GLUTATHIONE AT PH 3.4'''
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===ACYL-ENZYME INTERMEDIATE BETWEEN ALR0975 AND GLUTATHIONE AT PH 3.4===
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==Overview==
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Phytochelatin synthase (PCS) is a key enzyme for heavy-metal detoxification in plants. PCS catalyzes the production of glutathione (GSH)-derived peptides (called phytochelatins or PCs) that bind heavy-metal ions before vacuolar sequestration. The enzyme can also hydrolyze GSH and GS-conjugated xenobiotics. In the cyanobacterium Nostoc, the enzyme (NsPCS) contains only the catalytic domain of the eukaryotic synthase and can act as a GSH hydrolase and weakly as a peptide ligase. The crystal structure of NsPCS in its native form solved at a 2.0-A resolution shows that NsPCS is a dimer that belongs to the papain superfamily of cysteine proteases, with a conserved catalytic machinery. Moreover, the structure of the protein solved as a complex with GSH at a 1.4-A resolution reveals a gamma-glutamyl cysteine acyl-enzyme intermediate stabilized in a cavity of the protein adjacent to a second putative GSH binding site. GSH hydrolase and PCS activities of the enzyme are discussed in the light of both structures.
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The line below this paragraph, {{ABSTRACT_PUBMED_16339904}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16339904 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16339904}}
==About this Structure==
==About this Structure==
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[[Category: Phytochelatin synthase]]
[[Category: Phytochelatin synthase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:47:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:20:23 2008''

Revision as of 11:20, 29 July 2008

Image:2bu3.png

Template:STRUCTURE 2bu3

ACYL-ENZYME INTERMEDIATE BETWEEN ALR0975 AND GLUTATHIONE AT PH 3.4

Template:ABSTRACT PUBMED 16339904

About this Structure

2BU3 is a Single protein structure of sequence from Anabaena sp.. Full crystallographic information is available from OCA.

Reference

A papain-like enzyme at work: native and acyl-enzyme intermediate structures in phytochelatin synthesis., Vivares D, Arnoux P, Pignol D, Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18848-53. Epub 2005 Dec 9. PMID:16339904

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