2f9b

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[[Image:2f9b.gif|left|200px]]
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{{STRUCTURE_2f9b| PDB=2f9b | SCENE= }}
{{STRUCTURE_2f9b| PDB=2f9b | SCENE= }}
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'''Discovery of Novel Heterocyclic Factor VIIa Inhibitors'''
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===Discovery of Novel Heterocyclic Factor VIIa Inhibitors===
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==Overview==
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Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridine scaffold.
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(as it appears on PubMed at http://www.pubmed.gov), where 16460932 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16460932}}
==Disease==
==Disease==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Short hydrogen bond]]
[[Category: Short hydrogen bond]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:37:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:20:50 2008''

Revision as of 11:20, 29 July 2008

Image:2f9b.png

Template:STRUCTURE 2f9b

Contents

Discovery of Novel Heterocyclic Factor VIIa Inhibitors

Template:ABSTRACT PUBMED 16460932

Disease

Known disease associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]

About this Structure

2F9B is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of novel heterocyclic factor VIIa inhibitors., Rai R, Kolesnikov A, Sprengeler PA, Torkelson S, Ton T, Katz BA, Yu C, Hendrix J, Shrader WD, Stephens R, Cabuslay R, Sanford E, Young WB, Bioorg Med Chem Lett. 2006 Apr 15;16(8):2270-3. Epub 2006 Feb 3. PMID:16460932

Page seeded by OCA on Tue Jul 29 14:20:50 2008

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