2zjr

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{{Seed}}
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{{STRUCTURE_2zjr| PDB=2zjr | SCENE= }}
{{STRUCTURE_2zjr| PDB=2zjr | SCENE= }}
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'''Refined native structure of the large ribosomal subunit (50S) from Deinococcus radiodurans'''
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===Refined native structure of the large ribosomal subunit (50S) from Deinococcus radiodurans===
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==Overview==
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The thiopeptide class of antibiotics targets the GTPase-associated center (GAC) of the ribosome to inhibit translation factor function. Using X-ray crystallography, we have determined the binding sites of thiostrepton (Thio), nosiheptide (Nosi), and micrococcin (Micro), on the Deinococcus radiodurans large ribosomal subunit. The thiopeptides, by binding within a cleft located between the ribosomal protein L11 and helices 43 and 44 of the 23S rRNA, overlap with the position of domain V of EF-G, thus explaining how this class of drugs perturbs translation factor binding to the ribosome. The presence of Micro leads to additional density for the C-terminal domain (CTD) of L7, adjacent to and interacting with L11. The results suggest that L11 acts as a molecular switch to control L7 binding and plays a pivotal role in positioning one L7-CTD monomer on the G' subdomain of EF-G to regulate EF-G turnover during protein synthesis.
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(as it appears on PubMed at http://www.pubmed.gov), where 18406324 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18406324}}
==About this Structure==
==About this Structure==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:07:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:21:00 2008''

Revision as of 11:21, 29 July 2008

Image:2zjr.png

Template:STRUCTURE 2zjr

Refined native structure of the large ribosomal subunit (50S) from Deinococcus radiodurans

Template:ABSTRACT PUBMED 18406324

About this Structure

2ZJR is a Protein complex structure of sequences from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin., Harms JM, Wilson DN, Schluenzen F, Connell SR, Stachelhaus T, Zaborowska Z, Spahn CM, Fucini P, Mol Cell. 2008 Apr 11;30(1):26-38. PMID:18406324

Page seeded by OCA on Tue Jul 29 14:21:00 2008

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