2okr

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[[Image:2okr.gif|left|200px]]
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{{STRUCTURE_2okr| PDB=2okr | SCENE= }}
{{STRUCTURE_2okr| PDB=2okr | SCENE= }}
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'''Crystal Structure of the P38a-MAPKAP kinase 2 Heterodimer'''
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===Crystal Structure of the P38a-MAPKAP kinase 2 Heterodimer===
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==Overview==
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The p38 signaling pathway is activated in response to cell stress and induces production of proinflammatory cytokines. P38alpha is phosphorylated and activated in response to cell stress by MKK3 and MKK6 and in turn phosphorylates a number of substrates, including MAPKAP kinase 2 (MK2). We have determined the crystal structure of the unphosphorylated p38alpha-MK2 heterodimer. The C-terminal regulatory domain of MK2 binds in the docking groove of p38alpha, and the ATP-binding sites of both kinases are at the heterodimer interface. The conformation suggests an extra mechanism in addition to the regulation of the p38alpha and MK2 phosphorylation states that prevents phosphorylation of substrates in the absence of cell stress. Addition of constitutively active MKK6-DD results in rapid phosphorylation of the p38alpha-MK2 heterodimer.
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(as it appears on PubMed at http://www.pubmed.gov), where 17255097 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17255097}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:06:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:24:31 2008''

Revision as of 11:24, 29 July 2008

Image:2okr.png

Template:STRUCTURE 2okr

Crystal Structure of the P38a-MAPKAP kinase 2 Heterodimer

Template:ABSTRACT PUBMED 17255097

About this Structure

2OKR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer., ter Haar E, Prabhakar P, Liu X, Lepre C, J Biol Chem. 2007 Mar 30;282(13):9733-9. Epub 2007 Jan 25. PMID:17255097

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