2nrn

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[[Image:2nrn.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2nrn| PDB=2nrn | SCENE= }}
{{STRUCTURE_2nrn| PDB=2nrn | SCENE= }}
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'''Self-assembly of coiled-coil tetramers in the 1.40 A structure of a leucine-zipper mutant'''
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===Self-assembly of coiled-coil tetramers in the 1.40 A structure of a leucine-zipper mutant===
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==Overview==
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The hydrophobic core of the GCN4 leucine-zipper dimerization domain is formed by a parallel helical association between nonpolar side chains at the a and d positions of the heptad repeat. Here we report a self-assembling coiled-coil array formed by the GCN4-pAe peptide that differs from the wild-type GCN4 leucine zipper by alanine substitutions at three charged e positions. GCN4-pAe is incompletely folded in normal solution conditions yet self-assembles into an antiparallel tetraplex in crystals by formation of unanticipated hydrophobic seams linking the last two heptads of two parallel double-stranded coiled coils. The GCN4-pAe tetramers in the lattice associate laterally through the identical interactions to those in the intramolecular dimer-dimer interface. The van der Waals packing interaction in the solid state controls extended supramolecular assembly of the protein, providing an unusual atomic scale view of a mesostructure.
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(as it appears on PubMed at http://www.pubmed.gov), where 17189475 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17189475}}
==About this Structure==
==About this Structure==
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[[Category: Protein structure]]
[[Category: Protein structure]]
[[Category: Tetramer]]
[[Category: Tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:49:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:26:36 2008''

Revision as of 11:26, 29 July 2008

Image:2nrn.png

Template:STRUCTURE 2nrn

Self-assembly of coiled-coil tetramers in the 1.40 A structure of a leucine-zipper mutant

Template:ABSTRACT PUBMED 17189475

About this Structure

2NRN is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Self-assembly of coiled-coil tetramers in the 1.40 A structure of a leucine-zipper mutant., Deng Y, Zheng Q, Liu J, Cheng CS, Kallenbach NR, Lu M, Protein Sci. 2007 Feb;16(2):323-8. Epub 2006 Dec 22. PMID:17189475

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