1sgl

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{{STRUCTURE_1sgl| PDB=1sgl | SCENE= }}
{{STRUCTURE_1sgl| PDB=1sgl | SCENE= }}
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'''The three-dimensional structure and X-ray sequence reveal that trichomaglin is a novel S-like ribonuclease'''
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===The three-dimensional structure and X-ray sequence reveal that trichomaglin is a novel S-like ribonuclease===
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==Overview==
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Trichomaglin is a protein isolated from root tuber of the plant Maganlin (Trichosanthes Lepiniate, Cucurbitaceae). The crystal structure of trichomaglin has been determined by multiple-isomorphous replacement and refined at 2.2 A resolution. The X-ray sequence was established, based on electron density combined with the experimentally determined N-terminal sequence, and the sequence information derived from mass spectroscopic analysis. X-ray sequence-based homolog search and the three-dimensional structure reveal that trichomaglin is a novel S-like RNase, which was confirmed by biological assay. Trichomaglin molecule contains an additional beta sheet in the HV(b) region, compared with the known plant RNase structures. Fourteen cystein residues form seven disulfide bridges, more than those in the other known structures of S- and S-like RNases. His43 and His105 are expected to be the catalytic acid and base, respectively. Four hydrosulfate ions are bound in the active site pocket, three of them mimicking the substrate binding sites.
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(as it appears on PubMed at http://www.pubmed.gov), where 15274921 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15274921}}
==About this Structure==
==About this Structure==
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[[Category: Trichomaglin]]
[[Category: Trichomaglin]]
[[Category: X-ray sequence]]
[[Category: X-ray sequence]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:40:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:28:19 2008''

Revision as of 11:28, 29 July 2008

Image:1sgl.png

Template:STRUCTURE 1sgl

The three-dimensional structure and X-ray sequence reveal that trichomaglin is a novel S-like ribonuclease

Template:ABSTRACT PUBMED 15274921

About this Structure

1SGL is a Single protein structure of sequence from Trichosanthes lepiniana. Full crystallographic information is available from OCA.

Reference

The three-dimensional structure and X-ray sequence reveal that trichomaglin is a novel S-like ribonuclease., Gan JH, Yu L, Wu J, Xu H, Choudhary JS, Blackstock WP, Liu WY, Xia ZX, Structure. 2004 Jun;12(6):1015-25. PMID:15274921

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