1zzb

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{{STRUCTURE_1zzb| PDB=1zzb | SCENE= }}
{{STRUCTURE_1zzb| PDB=1zzb | SCENE= }}
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'''Crystal Structure of CoII HppE in Complex with Substrate'''
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===Crystal Structure of CoII HppE in Complex with Substrate===
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==Overview==
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The biosynthetic pathway of the clinically important antibiotic fosfomycin uses enzymes that catalyse reactions without precedent in biology. Among these is hydroxypropylphosphonic acid epoxidase, which represents a new subfamily of non-haem mononuclear iron enzymes. Here we present six X-ray structures of this enzyme: the apoenzyme at 2.0 A resolution; a native Fe(II)-bound form at 2.4 A resolution; a tris(hydroxymethyl)aminomethane-Co(II)-enzyme complex structure at 1.8 A resolution; a substrate-Co(II)-enzyme complex structure at 2.5 A resolution; and two substrate-Fe(II)-enzyme complexes at 2.1 and 2.3 A resolution. These structural data lead us to suggest how this enzyme is able to recognize and respond to its substrate with a conformational change that protects the radical-based intermediates formed during catalysis. Comparisons with other family members suggest why substrate binding is able to prime iron for dioxygen binding in the absence of alpha-ketoglutarate (a co-substrate required by many mononuclear iron enzymes), and how the unique epoxidation reaction of hydroxypropylphosphonic acid epoxidase may occur.
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The line below this paragraph, {{ABSTRACT_PUBMED_16015285}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16015285 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16015285}}
==About this Structure==
==About this Structure==
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[[Category: Holo-hppe]]
[[Category: Holo-hppe]]
[[Category: Mononuclear iron enzyme]]
[[Category: Mononuclear iron enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:16:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:30:09 2008''

Revision as of 11:30, 29 July 2008

Image:1zzb.png

Template:STRUCTURE 1zzb

Crystal Structure of CoII HppE in Complex with Substrate

Template:ABSTRACT PUBMED 16015285

About this Structure

1ZZB is a Single protein structure of sequence from Streptomyces wedmorensis. Full crystallographic information is available from OCA.

Reference

Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme., Higgins LJ, Yan F, Liu P, Liu HW, Drennan CL, Nature. 2005 Oct 6;437(7060):838-44. Epub 2005 Jul 13. PMID:16015285

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