1y3k

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{{STRUCTURE_1y3k| PDB=1y3k | SCENE= }}
{{STRUCTURE_1y3k| PDB=1y3k | SCENE= }}
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'''Solution structure of the apo form of the fifth domain of Menkes protein'''
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===Solution structure of the apo form of the fifth domain of Menkes protein===
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==Overview==
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The interaction between the human copper(I) chaperone, HAH1, and one of its two physiological partners, the Menkes disease protein (ATP7A), was investigated in solution using heteronuclear NMR. The study was carried out through titrations involving HAH1 and either the second or the fifth soluble domains of ATP7A (MNK2 and MNK5, respectively), in the presence of copper(I). The copper-transfer properties of MNK2 and MNK5 are similar, and differ significantly from those previously observed for the yeast homologous system. In particular, no stable adduct is formed between either of the MNK domains and HAH1. The copper(I) transfer reaction is slow on the time scale of the NMR chemical shift, and the equilibrium is significantly shifted towards the formation of copper(I)-MNK2/MNK5. The solution structures of both apo- and copper(I)-MNK5, which were not available, are also reported. The results are discussed in comparison with the data available in the literature for the interaction between HAH1 and its partners from other spectroscopic techniques.
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(as it appears on PubMed at http://www.pubmed.gov), where 15670166 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15670166}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1Y3K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3K OCA].
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1Y3K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3K OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural proteomics in europe]]
[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:14:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:30:39 2008''

Revision as of 11:30, 29 July 2008

Image:1y3k.png

Template:STRUCTURE 1y3k

Contents

Solution structure of the apo form of the fifth domain of Menkes protein

Template:ABSTRACT PUBMED 15670166

Disease

Known disease associated with this structure: Cutis laxa, neonatal OMIM:[300011], Menkes disease OMIM:[300011], Occipital horn syndrome OMIM:[300011]

About this Structure

1Y3K is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

An NMR study of the interaction between the human copper(I) chaperone and the second and fifth metal-binding domains of the Menkes protein., Banci L, Bertini I, Ciofi-Baffoni S, Chasapis CT, Hadjiliadis N, Rosato A, FEBS J. 2005 Feb;272(3):865-71. PMID:15670166

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