1rxl

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[[Image:1rxl.gif|left|200px]]
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{{Seed}}
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[[Image:1rxl.png|left|200px]]
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{{STRUCTURE_1rxl| PDB=1rxl | SCENE= }}
{{STRUCTURE_1rxl| PDB=1rxl | SCENE= }}
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'''Solution structure of the engineered protein Afae-dsc'''
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===Solution structure of the engineered protein Afae-dsc===
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==Overview==
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Pathogenic bacteria possess adhesion protein complexes that play essential roles in targeting host cells and in propagating infection. Although each family of adhesion proteins is generally associated with a specific human disease, the Dr family from Escherichia coli is a notable exception, as its members are associated with both diarrheal and urinary tract infections. These proteins are reported to form both fimbrial and afimbrial structures at the bacterial cell surface and target a common host cell receptor, the decay-accelerating factor (DAF or CD55). Using the newly solved three-dimensional structure of AfaE, we have constructed a robust atomic resolution model that reveals the structural basis for assembly by donor strand complementation and for the architecture of capped surface fibers.
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(as it appears on PubMed at http://www.pubmed.gov), where 15327779 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15327779}}
==About this Structure==
==About this Structure==
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1RXL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXL OCA].
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1RXL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXL OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Upec]]
[[Category: Upec]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:01:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:31:01 2008''

Revision as of 11:31, 29 July 2008

Image:1rxl.png

Template:STRUCTURE 1rxl

Solution structure of the engineered protein Afae-dsc

Template:ABSTRACT PUBMED 15327779

About this Structure

1RXL is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

An atomic resolution model for assembly, architecture, and function of the Dr adhesins., Anderson KL, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, Chen HA, Urvil P, du Merle L, Barlow PN, Medof ME, Smith RA, Nowicki B, Le Bouguenec C, Lea SM, Matthews S, Mol Cell. 2004 Aug 27;15(4):647-57. PMID:15327779

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