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2f08

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{{STRUCTURE_2f08| PDB=2f08 | SCENE= }}
{{STRUCTURE_2f08| PDB=2f08 | SCENE= }}
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'''Crystal structure of a major house dust mite allergen, Derf 2'''
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===Crystal structure of a major house dust mite allergen, Derf 2===
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==Overview==
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Pyroglyphid house dust mites are a major source of allergens in house dust. Mite allergens sensitize and induce asthma, rhinitis, and eczema in a large portion of patients with allergic diseases. Here, the crystal structure of a major mite allergen, Derf 2, derived from Dermatophagoides farinae was solved by single isomorphous replacement method with anomalous scattering (SIRAS) at 2.1A resolution. The present study also demonstrated that the conformation of the allergen was critical in the determination of Th1/Th2 shift based on physicochemical and immunological analyses. This indicates that rigidly folded and singly dispersed structure is essentially required for the generation of Th2 type cells by the allergen, while conformational variant protein leads to Th1 skewing, irrespective of the same amino acid sequence. This structure/function relationship may allow us to develop a novel strategy for hyposensitization therapy in patients with allergic diseases triggered by house dust mite allergens.
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(as it appears on PubMed at http://www.pubmed.gov), where 16313885 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16313885}}
==About this Structure==
==About this Structure==
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[[Category: Tanaka, Y.]]
[[Category: Tanaka, Y.]]
[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:18:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:33:10 2008''

Revision as of 11:33, 29 July 2008

Image:2f08.png

Template:STRUCTURE 2f08

Crystal structure of a major house dust mite allergen, Derf 2

Template:ABSTRACT PUBMED 16313885

About this Structure

2F08 is a Single protein structure of sequence from Dermatophagoides farinae. Full crystallographic information is available from OCA.

Reference

Crystal structure and some properties of a major house dust mite allergen, Derf 2., Suzuki M, Tanaka Y, Korematsu S, Mikami B, Minato N, Biochem Biophys Res Commun. 2006 Jan 13;339(2):679-86. Epub 2005 Nov 21. PMID:16313885

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