2z4f

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[[Image:2z4f.gif|left|200px]]
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{{Seed}}
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[[Image:2z4f.png|left|200px]]
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{{STRUCTURE_2z4f| PDB=2z4f | SCENE= }}
{{STRUCTURE_2z4f| PDB=2z4f | SCENE= }}
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'''Solution structure of the Discoidin Domain of DDR2'''
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===Solution structure of the Discoidin Domain of DDR2===
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==Overview==
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Discoidin domain receptor (DDR) is a cell-surface receptor tyrosine kinase activated by the binding of its discoidin (DS) domain to fibrillar collagen. Here, we have determined the NMR structure of the DS domain in DDR2 (DDR2-DS domain), and identified the binding site to fibrillar collagen by transferred cross-saturation experiments. The DDR2-DS domain structure adopts a distorted jellyroll fold, consisting of eight beta-strands. The collagen-binding site is formed at the interloop trench, consisting of charged residues surrounded by hydrophobic residues. The surface profile of the collagen-binding site suggests that the DDR2-DS domain recognizes specific sites on fibrillar collagen. This study provides a molecular basis for the collagen-binding mode of the DDR2-DS domain.
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The line below this paragraph, {{ABSTRACT_PUBMED_17703188}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17703188 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17703188}}
==About this Structure==
==About this Structure==
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2Z4F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4F OCA].
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2Z4F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4F OCA].
==Reference==
==Reference==
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[[Category: Beta barrel]]
[[Category: Beta barrel]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 19:56:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:33:14 2008''

Revision as of 11:33, 29 July 2008

Image:2z4f.png

Template:STRUCTURE 2z4f

Solution structure of the Discoidin Domain of DDR2

Template:ABSTRACT PUBMED 17703188

About this Structure

2Z4F is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural basis of the collagen-binding mode of discoidin domain receptor 2., Ichikawa O, Osawa M, Nishida N, Goshima N, Nomura N, Shimada I, EMBO J. 2007 Sep 19;26(18):4168-76. Epub 2007 Aug 16. PMID:17703188

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