1wyy

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[[Image:1wyy.gif|left|200px]]
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{{Seed}}
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[[Image:1wyy.png|left|200px]]
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{{STRUCTURE_1wyy| PDB=1wyy | SCENE= }}
{{STRUCTURE_1wyy| PDB=1wyy | SCENE= }}
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'''Post-fusion hairpin conformation of the sars coronavirus spike glycoprotein'''
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===Post-fusion hairpin conformation of the sars coronavirus spike glycoprotein===
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==Overview==
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The coronavirus spike glycoprotein is a class I membrane fusion protein with two characteristic heptad repeat regions (HR1 and HR2) in its ectodomain. Here, we report the X-ray structure of a previously characterized HR1/HR2 complex of the severe acute respiratory syndrome coronavirus spike protein. As expected, the HR1 and HR2 segments are organized in antiparallel orientations within a rod-like molecule. The HR1 helices form an exceptionally long (120 A) internal coiled coil stabilized by hydrophobic and polar interactions. A striking arrangement of conserved asparagine and glutamine residues of HR1 propagates from two central chloride ions, providing hydrogen-bonding "zippers" that strongly constrain the path of the HR2 main chain, forcing it to adopt an extended conformation at either end of a short HR2 alpha-helix.
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The line below this paragraph, {{ABSTRACT_PUBMED_15840526}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15840526 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15840526}}
==About this Structure==
==About this Structure==
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[[Category: Severe acute respiratory syndrome]]
[[Category: Severe acute respiratory syndrome]]
[[Category: Viral protein]]
[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:19:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:33:17 2008''

Revision as of 11:33, 29 July 2008

Image:1wyy.png

Template:STRUCTURE 1wyy

Post-fusion hairpin conformation of the sars coronavirus spike glycoprotein

Template:ABSTRACT PUBMED 15840526

About this Structure

1WYY is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.

Reference

Central ions and lateral asparagine/glutamine zippers stabilize the post-fusion hairpin conformation of the SARS coronavirus spike glycoprotein., Duquerroy S, Vigouroux A, Rottier PJ, Rey FA, Bosch BJ, Virology. 2005 May 10;335(2):276-85. PMID:15840526

Page seeded by OCA on Tue Jul 29 14:33:17 2008

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