This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1s7l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1s7l.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1s7l.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1s7l| PDB=1s7l | SCENE= }}
{{STRUCTURE_1s7l| PDB=1s7l | SCENE= }}
-
'''RimL- Ribosomal L7/L12 alpha-N-protein acetyltransferase in complex with Coenzyme A (CoA-Cys134 Disulfide)'''
+
===RimL- Ribosomal L7/L12 alpha-N-protein acetyltransferase in complex with Coenzyme A (CoA-Cys134 Disulfide)===
-
==Overview==
+
<!--
-
RimL is responsible for converting the prokaryotic ribosomal protein from L12 to L7 by acetylation of its N-terminal amino group. We demonstrate that purified RimL is capable of posttranslationally acetylating L12, exhibiting a V(max) of 21 min(-1). We have also determined the apostructure of RimL from Salmonella typhimurium and its complex with coenzyme A, revealing a homodimeric oligomer with structural similarity to other Gcn5-related N-acetyltransferase superfamily members. A large central trough located at the dimer interface provides sufficient room to bind both L12 N-terminal helices. Structural and biochemical analysis indicates that RimL proceeds by single-step transfer rather than a covalent-enzyme intermediate. This is the first structure of a Gcn5-related N-acetyltransferase family member with demonstrated activity toward a protein N(alpha)-amino group and is a first step toward understanding the molecular basis for N(alpha)acetylation and its function in cellular regulation.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15817456}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15817456 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15817456}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Gnat]]
[[Category: Gnat]]
[[Category: L7/l12]]
[[Category: L7/l12]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:23:49 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:40:59 2008''

Revision as of 11:41, 29 July 2008

Image:1s7l.png

Template:STRUCTURE 1s7l

RimL- Ribosomal L7/L12 alpha-N-protein acetyltransferase in complex with Coenzyme A (CoA-Cys134 Disulfide)

Template:ABSTRACT PUBMED 15817456

About this Structure

1S7L is a Single protein structure of sequence from Salmonella typhimurium lt2. Full crystallographic information is available from OCA.

Reference

A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium., Vetting MW, de Carvalho LP, Roderick SL, Blanchard JS, J Biol Chem. 2005 Jun 10;280(23):22108-14. Epub 2005 Apr 6. PMID:15817456

Page seeded by OCA on Tue Jul 29 14:40:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1s7l"
Personal tools