1qd9
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(New page: 200px<br /><applet load="1qd9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qd9, resolution 1.70Å" /> '''Bacillus subtilis YA...)
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Revision as of 22:28, 20 November 2007
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Bacillus subtilis YABJ
Overview
The yabJ gene in Bacillus subtilis is required for adenine-mediated, repression of purine biosynthetic genes in vivo and codes for an, acid-soluble, 14-kDa protein. The molecular mechanism of YabJ is unknown., YabJ is a member of a large, widely distributed family of proteins of, unknown biochemical function. The 1.7-A crystal structure of YabJ reveals, a trimeric organization with extensive buried hydrophobic surface and an, internal water-filled cavity. The most important finding in the structure, is a deep, narrow cleft between subunits lined with nine side chains that, are invariant among the 25 most similar homologs. This conserved site is, proposed to be a binding or catalytic site for a ligand or substrate that, is common to YabJ and other members of the YER057c/YjgF/UK114 family of, proteins.
About this Structure
1QD9 is a Single protein structure of sequence from Bacillus subtilis with HG, EMC and ACY as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family., Sinha S, Rappu P, Lange SC, Mantsala P, Zalkin H, Smith JL, Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13074-9. PMID:10557275
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