1yp1

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{{STRUCTURE_1yp1| PDB=1yp1 | SCENE= }}
{{STRUCTURE_1yp1| PDB=1yp1 | SCENE= }}
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'''Crystal structure of a non-hemorrhagic fibrin(ogen)olytic metalloproteinase from venom of Agkistrodon acutus'''
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===Crystal structure of a non-hemorrhagic fibrin(ogen)olytic metalloproteinase from venom of Agkistrodon acutus===
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==Overview==
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Thrombotic occlusive diseases pose a great threat to human health. Thrombolytic agents are in widespread use for the dissolution of arterial and venous pathologic thrombi in these kinds of diseases. Snake venom metalloproteinases (SVMPs) can act directly on fibrin/fibrinogen and are therefore potential candidates for therapeutic use against thrombotic occlusive diseases. In this study, we have determined the crystal structure of FII, a novel non-hemorrhagic SVMP isolated from Anhui Agkistrodon acutus snake venom by molecular replacement. The structure reveals that FII is a member of the P-I class SVMPs. The Zn2+ ion essential for hydrolytic activity is found in the active site and is tetrahedrally co-ordinated by three histidine residues and water molecule. Unambiguous electron density for a tri-peptide with sequence KNL is also found located near the active site. Biochemical evidences show that the tri-peptide KNL can inhibit the enzymatic activity of FII.
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(as it appears on PubMed at http://www.pubmed.gov), where 16330227 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16330227}}
==About this Structure==
==About this Structure==
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[[Category: Rao, Z.]]
[[Category: Rao, Z.]]
[[Category: Fii crystal structure]]
[[Category: Fii crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:36:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:41:55 2008''

Revision as of 11:42, 29 July 2008

Image:1yp1.png

Template:STRUCTURE 1yp1

Crystal structure of a non-hemorrhagic fibrin(ogen)olytic metalloproteinase from venom of Agkistrodon acutus

Template:ABSTRACT PUBMED 16330227

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a non-hemorrhagic fibrin(ogen)olytic metalloproteinase complexed with a novel natural tri-peptide inhibitor from venom of Agkistrodon acutus., Lou Z, Hou J, Liang X, Chen J, Qiu P, Liu Y, Li M, Rao Z, Yan G, J Struct Biol. 2005 Dec;152(3):195-203. Epub 2005 Nov 16. PMID:16330227

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