2c6d

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{{STRUCTURE_2c6d| PDB=2c6d | SCENE= }}
{{STRUCTURE_2c6d| PDB=2c6d | SCENE= }}
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'''AURORA A KINASE ACTIVATED MUTANT (T287D) IN COMPLEX WITH ADPNP'''
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===AURORA A KINASE ACTIVATED MUTANT (T287D) IN COMPLEX WITH ADPNP===
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==Overview==
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A novel series of 5-aminopyrimidinyl quinazolines has been developed from anilino-quinazoline 1, which was identified in a high throughput screen for Aurora A. Introduction of the pyrimidine ring and optimisation of the substituents both on this ring and at the C7 position of the quinazoline led to the discovery of compounds that are highly specific Aurora kinase inhibitors. Co-crystallisation of one of these inhibitors with a fragment of Aurora A shows the importance of the benzamido group in achieving selectivity.
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(as it appears on PubMed at http://www.pubmed.gov), where 16337122 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16337122}}
==About this Structure==
==About this Structure==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:19:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:46:12 2008''

Revision as of 11:46, 29 July 2008

Image:2c6d.png

Template:STRUCTURE 2c6d

AURORA A KINASE ACTIVATED MUTANT (T287D) IN COMPLEX WITH ADPNP

Template:ABSTRACT PUBMED 16337122

About this Structure

2C6D is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors., Heron NM, Anderson M, Blowers DP, Breed J, Eden JM, Green S, Hill GB, Johnson T, Jung FH, McMiken HH, Mortlock AA, Pannifer AD, Pauptit RA, Pink J, Roberts NJ, Rowsell S, Bioorg Med Chem Lett. 2006 Mar 1;16(5):1320-3. Epub 2005 Dec 5. PMID:16337122

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