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301d

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{{STRUCTURE_301d| PDB=301d | SCENE= }}
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'''CAPTURING THE STRUCTURE OF A CATALYTIC RNA INTERMEDIATE: RNA HAMMERHEAD RIBOZYME, MG(II)-SOAKED'''
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===CAPTURING THE STRUCTURE OF A CATALYTIC RNA INTERMEDIATE: RNA HAMMERHEAD RIBOZYME, MG(II)-SOAKED===
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==Overview==
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The crystal structure of an unmodified hammerhead RNA in the absence of divalent metal ions has been solved, and it was shown that this ribozyme can cleave itself in the crystal when divalent metal ions are added. This biologically active RNA fold is the same as that found previously for two modified hammerhead ribozymes. Addition of divalent cations at low pH makes it possible to capture the uncleaved RNA in metal-bound form. A conformational intermediate, having an additional Mg(II) bound to the cleavage-site phosphate, was captured by freeze-trapping the RNA at an active pH prior to cleavage. The most significant conformational changes were limited to the active site of the ribozyme, and the changed conformation requires only small additional movements to reach a proposed transition-state.
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The line below this paragraph, {{ABSTRACT_PUBMED_8953035}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8953035 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8953035}}
==About this Structure==
==About this Structure==
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[[Category: Loop]]
[[Category: Loop]]
[[Category: Rna hammerhead ribozyme]]
[[Category: Rna hammerhead ribozyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:14:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:48:12 2008''

Revision as of 11:48, 29 July 2008

Image:301d.png

Template:STRUCTURE 301d

CAPTURING THE STRUCTURE OF A CATALYTIC RNA INTERMEDIATE: RNA HAMMERHEAD RIBOZYME, MG(II)-SOAKED

Template:ABSTRACT PUBMED 8953035

About this Structure

Full crystallographic information is available from OCA.

Reference

Capturing the structure of a catalytic RNA intermediate: the hammerhead ribozyme., Scott WG, Murray JB, Arnold JR, Stoddard BL, Klug A, Science. 1996 Dec 20;274(5295):2065-9. PMID:8953035

Page seeded by OCA on Tue Jul 29 14:48:12 2008

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