2ayr

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[[Image:2ayr.gif|left|200px]]
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{{STRUCTURE_2ayr| PDB=2ayr | SCENE= }}
{{STRUCTURE_2ayr| PDB=2ayr | SCENE= }}
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'''A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats'''
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===A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats===
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==Overview==
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The design of a novel selective estrogen receptor modulator (SERM) for the potential treatment of uterine leiomyoma is described. 16 (LY2066948-HCl) binds with high affinity to estrogen receptors alpha and beta (ERalpha and ERbeta, respectively) and is a potent uterine antagonist with minimal effects on the ovaries as determined by serum biomarkers and histologic evaluation.
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(as it appears on PubMed at http://www.pubmed.gov), where 16250633 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16250633}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:38:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:50:43 2008''

Revision as of 11:50, 29 July 2008

Image:2ayr.png

Template:STRUCTURE 2ayr

A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats

Template:ABSTRACT PUBMED 16250633

About this Structure

2AYR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats., Hummel CW, Geiser AG, Bryant HU, Cohen IR, Dally RD, Fong KC, Frank SA, Hinklin R, Jones SA, Lewis G, McCann DJ, Rudmann DG, Shepherd TA, Tian H, Wallace OB, Wang M, Wang Y, Dodge JA, J Med Chem. 2005 Nov 3;48(22):6772-5. PMID:16250633

Page seeded by OCA on Tue Jul 29 14:50:43 2008

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