2hk5

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{{STRUCTURE_2hk5| PDB=2hk5 | SCENE= }}
{{STRUCTURE_2hk5| PDB=2hk5 | SCENE= }}
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'''Hck Kinase in Complex with Lck targetted Inhibitor PG-1009247'''
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===Hck Kinase in Complex with Lck targetted Inhibitor PG-1009247===
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==Overview==
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This communication details the synthesis, biological activity, and binding mode of a novel class of 2-benzimidazole substituted pyrimidines. The most potent analogs disclosed showed low nanomolar activity for the inhibition of Lck kinase and a representative analog was co-crystallized with Hck (a structurally related member of the Src family kinases).
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(as it appears on PubMed at http://www.pubmed.gov), where 16997556 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16997556}}
==About this Structure==
==About this Structure==
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[[Category: Src-family]]
[[Category: Src-family]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:23:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:56:50 2008''

Revision as of 11:56, 29 July 2008

Template:STRUCTURE 2hk5

Hck Kinase in Complex with Lck targetted Inhibitor PG-1009247

Template:ABSTRACT PUBMED 16997556

About this Structure

2HK5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck)., Sabat M, VanRens JC, Laufersweiler MJ, Brugel TA, Maier J, Golebiowski A, De B, Easwaran V, Hsieh LC, Walter RL, Mekel MJ, Evdokimov A, Janusz MJ, Bioorg Med Chem Lett. 2006 Dec 1;16(23):5973-7. Epub 2006 Sep 25. PMID:16997556

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