1ru7

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{{STRUCTURE_1ru7| PDB=1ru7 | SCENE= }}
{{STRUCTURE_1ru7| PDB=1ru7 | SCENE= }}
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'''1934 Human H1 Hemagglutinin'''
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===1934 Human H1 Hemagglutinin===
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==Overview==
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The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.
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(as it appears on PubMed at http://www.pubmed.gov), where 14764886 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14764886}}
==About this Structure==
==About this Structure==
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[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Hemagglutinin]]
[[Category: Hemagglutinin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:54:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:57:23 2008''

Revision as of 11:57, 29 July 2008

Image:1ru7.png

Template:STRUCTURE 1ru7

1934 Human H1 Hemagglutinin

Template:ABSTRACT PUBMED 14764886

About this Structure

1RU7 is a Protein complex structure of sequences from Influenza a virus. Full crystallographic information is available from OCA.

Reference

The structure and receptor binding properties of the 1918 influenza hemagglutinin., Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ, Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5. PMID:14764886

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