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1qf4
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(New page: 200px<br /><applet load="1qf4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qf4, resolution 2.2Å" /> '''DESIGN, SYNTHESIS, AN...)
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Revision as of 22:30, 20 November 2007
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DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE
Overview
Two relatively weak herbicides, hydantocidin phosphate and hadacidin were, linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is, shown) of the enzyme adenylosuccinate synthetase. The crystal structures, of the bisubstrate-enzyme complexes were determined.
About this Structure
1QF4 is a Single protein structure of sequence from Escherichia coli with PO4, MG, GDP and RPD as ligands. Active as Adenylosuccinate synthase, with EC number 6.3.4.4 Full crystallographic information is available from OCA.
Reference
An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase., Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW, Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:10556888
Page seeded by OCA on Wed Nov 21 00:37:37 2007
