2hd5

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{{STRUCTURE_2hd5| PDB=2hd5 | SCENE= }}
{{STRUCTURE_2hd5| PDB=2hd5 | SCENE= }}
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'''USP2 in complex with ubiquitin'''
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===USP2 in complex with ubiquitin===
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==Overview==
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Deubiquitinating proteases reverse protein ubiquitination and rescue their target proteins from destruction by the proteasome. USP2, a cysteine protease and a member of the ubiquitin specific protease family, is overexpressed in prostate cancer and stabilizes fatty acid synthase, which has been associated with the malignancy of some aggressive prostate cancers. Here, we report the structure of the human USP2 catalytic domain in complex with ubiquitin. Ubiquitin uses two major sites for the interaction with the protease. Both sites are required simultaneously, as shown by USP2 inhibition assays with peptides and ubiquitin mutants. In addition, a layer of ordered water molecules mediates key interactions between ubiquitin and USP2. As several of those molecules are found at identical positions in the previously solved USP7/ubiquitin-aldehyde complex structure, we suggest a general mechanism of water-mediated ubiquitin recognition by USPs.
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{{ABSTRACT_PUBMED_16905103}}
==About this Structure==
==About this Structure==
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[[Category: Deubiquitinating protease]]
[[Category: Deubiquitinating protease]]
[[Category: Substrate enzyme complex]]
[[Category: Substrate enzyme complex]]
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Revision as of 11:59, 29 July 2008

Image:2hd5.png

Template:STRUCTURE 2hd5

USP2 in complex with ubiquitin

Template:ABSTRACT PUBMED 16905103

About this Structure

2HD5 is a Protein complex structure of sequences from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of ubiquitin recognition by the deubiquitinating protease USP2., Renatus M, Parrado SG, D'Arcy A, Eidhoff U, Gerhartz B, Hassiepen U, Pierrat B, Riedl R, Vinzenz D, Worpenberg S, Kroemer M, Structure. 2006 Aug;14(8):1293-302. PMID:16905103

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