This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.


Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1sn6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1sn6.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1sn6.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1sn6| PDB=1sn6 | SCENE= }}
{{STRUCTURE_1sn6| PDB=1sn6 | SCENE= }}
-
'''NMR solution structure of human Saposin C in SDS micelles'''
+
===NMR solution structure of human Saposin C in SDS micelles===
-
==Overview==
+
<!--
-
Saposin C is a lysosomal, membrane-binding protein that acts as an activator for the hydrolysis of glucosylceramide by the enzyme glucocerebrosidase. We used high-resolution NMR to determine the three-dimensional solution structure of saposin C in the presence of the detergent sodium dodecyl sulfate (SDS). This structure provides the first representation of membrane bound saposin C at the atomic level. In the presence of SDS, the protein adopts an open conformation with an exposed hydrophobic pocket. In contrast, the previously reported NMR structure of saposin C in the absence of SDS is compact and contains a hydrophobic core that is not exposed to the solvent. NMR data indicate that the SDS molecules interact with the hydrophobic pocket. The structure of saposin C in the presence of SDS is very similar to a monomer in the saposin B homodimer structure. Their comparison reveals possible similarity in the type of protein/lipid interaction as well as structural components differentiating their quaternary structures and functional specificity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15713488}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15713488 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15713488}}
==Disease==
==Disease==
Line 19: Line 23:
==About this Structure==
==About this Structure==
-
1SN6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SN6 OCA].
+
1SN6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SN6 OCA].
==Reference==
==Reference==
Solution structure of human saposin C in a detergent environment., Hawkins CA, de Alba E, Tjandra N, J Mol Biol. 2005 Mar 11;346(5):1381-92. Epub 2005 Jan 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15713488 15713488]
Solution structure of human saposin C in a detergent environment., Hawkins CA, de Alba E, Tjandra N, J Mol Biol. 2005 Mar 11;346(5):1381-92. Epub 2005 Jan 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15713488 15713488]
 +
 +
Solution structure of human saposin C: pH-dependent interaction with phospholipid vesicles., de Alba E, Weiler S, Tjandra N, Biochemistry. 2003 Dec 23;42(50):14729-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14674747 14674747]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 31: Line 37:
[[Category: All alpha-helice]]
[[Category: All alpha-helice]]
[[Category: Alpha-helices connected by turn]]
[[Category: Alpha-helices connected by turn]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:54:45 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:00:37 2008''

Revision as of 12:00, 29 July 2008

Template:STRUCTURE 1sn6

Contents

NMR solution structure of human Saposin C in SDS micelles

Template:ABSTRACT PUBMED 15713488

Disease

Known disease associated with this structure: Combined SAP deficiency OMIM:[176801], Gaucher disease, atypical OMIM:[176801], Krabbe disease, atypical OMIM:[176801], Metachromatic leukodystrophy due to SAP-b deficiency OMIM:[176801]

About this Structure

1SN6 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of human saposin C in a detergent environment., Hawkins CA, de Alba E, Tjandra N, J Mol Biol. 2005 Mar 11;346(5):1381-92. Epub 2005 Jan 20. PMID:15713488

Solution structure of human saposin C: pH-dependent interaction with phospholipid vesicles., de Alba E, Weiler S, Tjandra N, Biochemistry. 2003 Dec 23;42(50):14729-40. PMID:14674747

Page seeded by OCA on Tue Jul 29 15:00:37 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools