2jym

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{{STRUCTURE_2jym| PDB=2jym | SCENE= }}
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'''Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element'''
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===Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element===
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==Overview==
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Chronic hepatitis B virus (HBV) infections may lead to severe diseases like liver cirrhosis or hepatocellular carcinoma (HCC). The HBV post-transcriptional regulatory element (HPRE) facilitates the nuclear export of unspliced viral mRNAs, contains a splicing regulatory element and resides in the 3'-region of all viral transcripts. The HPRE consists of three sub-elements alpha (nucleotides 1151-1346), beta1 (nucleotides 1347-1457) and beta2 (nucleotides 1458-1582), which confer together full export competence. Here, we present the NMR solution structure (pdb 2JYM) of the stem-loop alpha (SLalpha, nucleotides 1292-1321) located in the sub-element alpha. The SLalpha contains a CAGGC pentaloop highly conserved in hepatoviruses, which essentially adopts a CUNG-like tetraloop conformation. Furthermore, the SLalpha harbours a single bulged G residue flanked by A-helical regions. The structure is highly suggestive of serving two functions in the context of export of unspliced viral RNA: binding sterile alpha motif (SAM-) domain containing proteins and/or preventing the utilization of a 3'-splice site contained within SLalpha.
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(as it appears on PubMed at http://www.pubmed.gov), where 18263618 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18263618}}
==About this Structure==
==About this Structure==
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2JYM is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYM OCA].
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2JYM is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYM OCA].
==Reference==
==Reference==
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[[Category: Rna]]
[[Category: Rna]]
[[Category: Stem-loop alpha]]
[[Category: Stem-loop alpha]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 12:50:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:03:41 2008''

Revision as of 12:03, 29 July 2008

Image:2jym.png

Template:STRUCTURE 2jym

Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element

Template:ABSTRACT PUBMED 18263618

About this Structure

2JYM is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element., Schwalbe M, Ohlenschlager O, Marchanka A, Ramachandran R, Hafner S, Heise T, Gorlach M, Nucleic Acids Res. 2008 Mar;36(5):1681-9. Epub 2008 Feb 7. PMID:18263618

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