1toz

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{{STRUCTURE_1toz| PDB=1toz | SCENE= }}
{{STRUCTURE_1toz| PDB=1toz | SCENE= }}
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'''NMR structure of the human NOTCH-1 ligand binding region'''
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===NMR structure of the human NOTCH-1 ligand binding region===
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==Overview==
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We present NMR structural and dynamics analysis of the putative ligand binding region of human Notch-1, comprising EGF-like domains 11-13. Functional integrity of an unglycosylated, recombinant fragment was confirmed by calcium-dependent binding of tetrameric complexes to ligand-expressing cells. EGF modules 11 and 12 adopt a well-defined, rod-like orientation rigidified by calcium. The interdomain tilt is similar to that found in previously studied calcium binding EGF pairs, but the angle of twist is significantly different. This leads to an extended double-stranded beta sheet structure, spanning the two EGF modules. Based on the conservation of residues involved in interdomain hydrophobic packing, we propose this arrangement to be prototypical of a distinct class of EGF linkages. On this premise, we have constructed a model of the 36 EGF modules of the Notch extracellular domain that enables predictions to be made about the general role of calcium binding to this region.
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(as it appears on PubMed at http://www.pubmed.gov), where 15576031 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15576031}}
==About this Structure==
==About this Structure==
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1TOZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOZ OCA].
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1TOZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOZ OCA].
==Reference==
==Reference==
Structural and functional properties of the human notch-1 ligand binding region., Hambleton S, Valeyev NV, Muranyi A, Knott V, Werner JM, McMichael AJ, Handford PA, Downing AK, Structure. 2004 Dec;12(12):2173-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15576031 15576031]
Structural and functional properties of the human notch-1 ligand binding region., Hambleton S, Valeyev NV, Muranyi A, Knott V, Werner JM, McMichael AJ, Handford PA, Downing AK, Structure. 2004 Dec;12(12):2173-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15576031 15576031]
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1H, 13C, and 15N resonance assignments of human Notch-1 calcium binding EGF domains 11-13., Muranyi A, Hambleton S, Knott V, McMichael A, Handford PA, Downing AK, J Biomol NMR. 2004 Jul;29(3):443-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15213460 15213460]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Module]]
[[Category: Module]]
[[Category: Notch]]
[[Category: Notch]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:07:27 2008''

Revision as of 12:07, 29 July 2008

Image:1toz.png

Template:STRUCTURE 1toz

NMR structure of the human NOTCH-1 ligand binding region

Template:ABSTRACT PUBMED 15576031

About this Structure

1TOZ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural and functional properties of the human notch-1 ligand binding region., Hambleton S, Valeyev NV, Muranyi A, Knott V, Werner JM, McMichael AJ, Handford PA, Downing AK, Structure. 2004 Dec;12(12):2173-83. PMID:15576031

1H, 13C, and 15N resonance assignments of human Notch-1 calcium binding EGF domains 11-13., Muranyi A, Hambleton S, Knott V, McMichael A, Handford PA, Downing AK, J Biomol NMR. 2004 Jul;29(3):443-4. PMID:15213460

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