1npo

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[[Image:1npo.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1npo| PDB=1npo | SCENE= }}
{{STRUCTURE_1npo| PDB=1npo | SCENE= }}
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'''BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN'''
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===BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN===
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==Overview==
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The first crystal structure of the pituitary hormone oxytocin complexed with its carrier protein neurophysin has been determined and refined to 3.0 A resolution. The hormone-binding site is located at the end of a 3(10)-helix and involves residues from both domains of each monomer. Hormone residues Tyr 2, which is buried deep in the binding pocket, and Cys 1 have been confirmed as the key residues involved in neurophysin-hormone recognition. We have compared the bound oxytocin observed in the neurophysin-oxytocin complex, the X-ray structures of unbound oxytocin analogues and the NMR-derived structure for bound oxytocin. We find that while our structure is in agreement with the previous crystallographic findings, it differs from the NMR result with regard to how Tyr 2 of the hormone is recognized by neurophysin.
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The line below this paragraph, {{ABSTRACT_PUBMED_8564543}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8564543 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8564543}}
==About this Structure==
==About this Structure==
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[[Category: Wang, B C.]]
[[Category: Wang, B C.]]
[[Category: Hypothalamus]]
[[Category: Hypothalamus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:49:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:10:36 2008''

Revision as of 12:10, 29 July 2008

Image:1npo.png

Template:STRUCTURE 1npo

BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN

Template:ABSTRACT PUBMED 8564543

About this Structure

1NPO is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the neurophysin-oxytocin complex., Rose JP, Wu CK, Hsiao CD, Breslow E, Wang BC, Nat Struct Biol. 1996 Feb;3(2):163-9. PMID:8564543

Page seeded by OCA on Tue Jul 29 15:10:36 2008

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