1uc8

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{{STRUCTURE_1uc8| PDB=1uc8 | SCENE= }}
{{STRUCTURE_1uc8| PDB=1uc8 | SCENE= }}
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'''Crystal structure of a lysine biosynthesis enzyme, Lysx, from thermus thermophilus HB8'''
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===Crystal structure of a lysine biosynthesis enzyme, Lysx, from thermus thermophilus HB8===
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==Overview==
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The thermophilic bacterium Thermus thermophilus synthesizes lysine through the alpha-aminoadipate pathway, which uses alpha-aminoadipate as a biosynthetic intermediate of lysine. LysX is the essential enzyme in this pathway, and is believed to catalyze the acylation of alpha-aminoadipate. We have determined the crystal structures of LysX and its complex with ADP at 2.0A and 2.38A resolutions, respectively. LysX is composed of three alpha+beta domains, each composed of a four to five-stranded beta-sheet core flanked by alpha-helices. The C-terminal and central domains form an ATP-grasp fold, which is responsible for ATP binding. LysX has two flexible loop regions, which are expected to play an important role in substrate binding and protection. In spite of the low level of sequence identity, the overall fold of LysX is surprisingly similar to that of other ATP-grasp fold proteins, such as D-Ala:D-Ala ligase, PurT-encoded glycinamide ribonucleotide transformylase, glutathione synthetase, and synapsin I. In particular, they share a similar spatial arrangement of the amino acid residues around the ATP-binding site. This observation strongly suggests that LysX is an ATP-utilizing enzyme that shares a common evolutionary ancestor with other ATP-grasp fold proteins possessing a carboxylate-amine/thiol ligase activity.
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{{ABSTRACT_PUBMED_12963379}}
==About this Structure==
==About this Structure==
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[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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Revision as of 12:11, 29 July 2008

Image:1uc8.png

Template:STRUCTURE 1uc8

Crystal structure of a lysine biosynthesis enzyme, Lysx, from thermus thermophilus HB8

Template:ABSTRACT PUBMED 12963379

About this Structure

1UC8 is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a lysine biosynthesis enzyme, LysX, from Thermus thermophilus HB8., Sakai H, Vassylyeva MN, Matsuura T, Sekine S, Gotoh K, Nishiyama M, Terada T, Shirouzu M, Kuramitsu S, Vassylyev DG, Yokoyama S, J Mol Biol. 2003 Sep 19;332(3):729-40. PMID:12963379

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