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2qzh

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[[Image:2qzh.gif|left|200px]]
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{{STRUCTURE_2qzh| PDB=2qzh | SCENE= }}
{{STRUCTURE_2qzh| PDB=2qzh | SCENE= }}
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'''SCR2/3 of DAF from the NMR structure 1nwv fitted into a cryoEM reconstruction of CVB3-RD complexed with DAF'''
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===SCR2/3 of DAF from the NMR structure 1nwv fitted into a cryoEM reconstruction of CVB3-RD complexed with DAF===
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==Overview==
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Many entero-, parecho-, and rhinoviruses use immunoglobulin (Ig)-like receptors that bind into the viral canyon and are required to initiate viral uncoating during infection. However, some of these viruses use an alternative or additional receptor that binds outside the canyon. Both the coxsackievirus-adenovirus receptor (CAR), an Ig-like molecule that binds into the viral canyon, and decay-accelerating factor (DAF) have been identified as cellular receptors for coxsackievirus B3 (CVB3). A cryoelectron microscopy reconstruction of a variant of CVB3 complexed with DAF shows full occupancy of the DAF receptor in each of 60 binding sites. The DAF molecule bridges the canyon, blocking the CAR binding site and causing the two receptors to compete with one another. The binding site of DAF on CVB3 differs from the binding site of DAF on the surface of echoviruses, suggesting independent evolutionary processes.
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The line below this paragraph, {{ABSTRACT_PUBMED_17804498}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17804498 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17804498}}
==About this Structure==
==About this Structure==
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[[Category: Scr2/3 of daf fitted into cryoem density of cvb3-rd complexed with daf]]
[[Category: Scr2/3 of daf fitted into cryoem density of cvb3-rd complexed with daf]]
[[Category: Sushi]]
[[Category: Sushi]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:58:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:13:50 2008''

Revision as of 12:13, 29 July 2008

Image:2qzh.png

Template:STRUCTURE 2qzh

SCR2/3 of DAF from the NMR structure 1nwv fitted into a cryoEM reconstruction of CVB3-RD complexed with DAF

Template:ABSTRACT PUBMED 17804498

About this Structure

2QZH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Interaction of decay-accelerating factor with coxsackievirus B3., Hafenstein S, Bowman VD, Chipman PR, Bator Kelly CM, Lin F, Medof ME, Rossmann MG, J Virol. 2007 Dec;81(23):12927-35. Epub 2007 Sep 5. PMID:17804498

Page seeded by OCA on Tue Jul 29 15:13:50 2008

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