1r6z

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{{STRUCTURE_1r6z| PDB=1r6z | SCENE= }}
{{STRUCTURE_1r6z| PDB=1r6z | SCENE= }}
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'''The Crystal Structure of the Argonaute2 PAZ domain (as a MBP fusion)'''
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===The Crystal Structure of the Argonaute2 PAZ domain (as a MBP fusion)===
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==Overview==
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RISC, the RNA-induced silencing complex, uses short interfering RNAs (siRNAs) or micro RNAs (miRNAs) to select its targets in a sequence-dependent manner. Key RISC components are Argonaute proteins, which contain two characteristic domains, PAZ and PIWI. PAZ is highly conserved and is found only in Argonaute proteins and Dicer. We have solved the crystal structure of the PAZ domain of Drosophila Argonaute2. The PAZ domain contains a variant of the OB fold, a module that often binds single-stranded nucleic acids. PAZ domains show low-affinity nucleic acid binding, probably interacting with the 3' ends of single-stranded regions of RNA. PAZ can bind the characteristic two-base 3' overhangs of siRNAs, indicating that although PAZ may not be a primary nucleic acid binding site in Dicer or RISC, it may contribute to the specific and productive incorporation of siRNAs and miRNAs into the RNAi pathway.
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(as it appears on PubMed at http://www.pubmed.gov), where 14625589 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14625589}}
==About this Structure==
==About this Structure==
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[[Category: Deviant ob fold]]
[[Category: Deviant ob fold]]
[[Category: Rnai]]
[[Category: Rnai]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:09:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:13:55 2008''

Revision as of 12:14, 29 July 2008

Image:1r6z.png

Template:STRUCTURE 1r6z

The Crystal Structure of the Argonaute2 PAZ domain (as a MBP fusion)

Template:ABSTRACT PUBMED 14625589

About this Structure

1R6Z is a Single protein structure of sequence from Escherichia coli, drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes., Song JJ, Liu J, Tolia NH, Schneiderman J, Smith SK, Martienssen RA, Hannon GJ, Joshua-Tor L, Nat Struct Biol. 2003 Dec;10(12):1026-32. Epub 2003 Nov 16. PMID:14625589

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