1qg9
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(New page: 200px<br /><applet load="1qg9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qg9" /> '''SECOND REPEAT (IS2MIC) FROM VOLTAGE-GATED SO...)
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Revision as of 22:32, 20 November 2007
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SECOND REPEAT (IS2MIC) FROM VOLTAGE-GATED SODIUM CHANNEL
Overview
Peptides representing transmembrane regions of the alpha-subunit of the, voltage-gated sodium channel were synthesised and their structures, analysed, using 1H NMR and CD, in trifluoroethanol and in, dodecylphosphocholine micelles. Sequence analysis suggests that the, channel has six regions, S1 to S6, predicted to span the membrane in four, homologous domains, designated, I, II, III and IV. Presented here are, studies of representatives examples of possible single spanning segments, (IS2, IS4, IVS4) and a double spanning segment, IS34, composed of segments, IS3 and IS4. In addition, we investigated ISlink56, the putative linker, region between segments IS5 and IS6. All of the peptides were found to, have predominantly alpha-helical structures in both solvent systems. There, was some evidence for bending of the longer helices but there was no, discernible evidence for well-defined tertiary structure.
About this Structure
1QG9 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Structural studies of synthetic peptides dissected from the voltage-gated sodium channel., Doak DG, Mulvey D, Kawaguchi K, Villalain J, Campbell ID, J Mol Biol. 1996 May 17;258(4):672-87. PMID:8637001
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