1s4r

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[[Image:1s4r.jpg|left|200px]]
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{{STRUCTURE_1s4r| PDB=1s4r | SCENE= }}
{{STRUCTURE_1s4r| PDB=1s4r | SCENE= }}
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'''Structure of a reaction intermediate in the photocycle of PYP extracted by a SVD-driven analysis'''
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===Structure of a reaction intermediate in the photocycle of PYP extracted by a SVD-driven analysis===
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==Overview==
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We determine the number of authentic reaction intermediates in the later stages of the photocycle of photoactive yellow protein at room temperature, their atomic structures, and a consistent set of chemical kinetic mechanisms, by analysis of a set of time-dependent difference electron density maps spanning the time range from 5 micros to 100 ms. The successful fit of exponentials to right singular vectors derived from a singular value decomposition of the difference maps demonstrates that a chemical kinetic mechanism holds and that structurally distinct intermediates exist. We identify two time-independent difference maps, from which we refine the structures of the corresponding intermediates. We thus demonstrate how structures associated with intermediate states can be extracted from the experimental, time-dependent crystallographic data. Stoichiometric and structural constraints allow the exclusion of one kinetic mechanism proposed for the photocycle but retain other plausible candidate kinetic mechanisms.
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The line below this paragraph, {{ABSTRACT_PUBMED_15041745}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15041745 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15041745}}
==About this Structure==
==About this Structure==
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[[Category: Srajer, V.]]
[[Category: Srajer, V.]]
[[Category: Reaction intermediate]]
[[Category: Reaction intermediate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:17:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:18:52 2008''

Revision as of 12:18, 29 July 2008

Image:1s4r.png

Template:STRUCTURE 1s4r

Structure of a reaction intermediate in the photocycle of PYP extracted by a SVD-driven analysis

Template:ABSTRACT PUBMED 15041745

About this Structure

1S4R is a Single protein structure of sequence from Halorhodospira halophila. Full crystallographic information is available from OCA.

Reference

Protein kinetics: structures of intermediates and reaction mechanism from time-resolved x-ray data., Schmidt M, Pahl R, Srajer V, Anderson S, Ren Z, Ihee H, Rajagopal S, Moffat K, Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4799-804. Epub 2004 Mar 23. PMID:15041745

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