2j5p

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[[Image:2j5p.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2j5p| PDB=2j5p | SCENE= }}
{{STRUCTURE_2j5p| PDB=2j5p | SCENE= }}
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'''E. COLI FTSK GAMMA DOMAIN'''
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===E. COLI FTSK GAMMA DOMAIN===
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==Overview==
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The bacterial septum-located DNA translocase FtsK coordinates circular chromosome segregation with cell division. Rapid translocation of DNA by FtsK is directed by 8-base-pair DNA motifs (KOPS), so that newly replicated termini are brought together at the developing septum, thereby facilitating completion of chromosome segregation. Translocase functions reside in three domains, alpha, beta and gamma. FtsKalphabeta are necessary and sufficient for ATP hydrolysis-dependent DNA translocation, which is modulated by FtsKgamma through its interaction with KOPS. By solving the FtsKgamma structure by NMR, we show that gamma is a winged-helix domain. NMR chemical shift mapping localizes the DNA-binding site on the gamma domain. Mutated proteins with substitutions in the FtsKgamma DNA-recognition helix are impaired in DNA binding and KOPS recognition, yet remain competent in DNA translocation and XerCD-dif site-specific recombination, which facilitates the late stages of chromosome segregation.
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(as it appears on PubMed at http://www.pubmed.gov), where 17057717 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17057717}}
==About this Structure==
==About this Structure==
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2J5P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5P OCA].
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2J5P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5P OCA].
==Reference==
==Reference==
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[[Category: Recombination]]
[[Category: Recombination]]
[[Category: Xercd]]
[[Category: Xercd]]
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Revision as of 12:19, 29 July 2008

Image:2j5p.png

Template:STRUCTURE 2j5p

E. COLI FTSK GAMMA DOMAIN

Template:ABSTRACT PUBMED 17057717

About this Structure

2J5P is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

The FtsK gamma domain directs oriented DNA translocation by interacting with KOPS., Sivanathan V, Allen MD, de Bekker C, Baker R, Arciszewska LK, Freund SM, Bycroft M, Lowe J, Sherratt DJ, Nat Struct Mol Biol. 2006 Nov;13(11):965-72. Epub 2006 Oct 22. PMID:17057717

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