This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1xof

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1xof.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1xof.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1xof| PDB=1xof | SCENE= }}
{{STRUCTURE_1xof| PDB=1xof | SCENE= }}
-
'''Heterooligomeric Beta Beta Alpha Miniprotein'''
+
===Heterooligomeric Beta Beta Alpha Miniprotein===
-
==Overview==
+
<!--
-
The study of short, autonomously folding peptides, or "miniproteins," is important for advancing our understanding of protein stability and folding specificity. Although many examples of synthetic alpha-helical structures are known, relatively few mixed alpha/beta structures have been successfully designed. Only one mixed-secondary structure oligomer, an alpha/beta homotetramer, has been reported thus far. In this report, we use structural analysis and computational design to convert this homotetramer into the smallest known alpha/beta-heterotetramer. Computational screening of many possible sequence/structure combinations led efficiently to the design of short, 21-residue peptides that fold cooperatively and autonomously into a specific complex in solution. A 1.95 A crystal structure reveals how steric complementarity and charge patterning encode heterospecificity. The first- and second-generation heterotetrameric miniproteins described here will be useful as simple models for the analysis of protein-protein interaction specificity and as structural platforms for the further elaboration of folding and function.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15698566}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15698566 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15698566}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Heterotetramer]]
[[Category: Heterotetramer]]
[[Category: Protein design]]
[[Category: Protein design]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:17:46 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:20:27 2008''

Revision as of 12:20, 29 July 2008

Image:1xof.png

Template:STRUCTURE 1xof

Heterooligomeric Beta Beta Alpha Miniprotein

Template:ABSTRACT PUBMED 15698566

About this Structure

Full crystallographic information is available from OCA.

Reference

Design of a heterospecific, tetrameric, 21-residue miniprotein with mixed alpha/beta structure., Ali MH, Taylor CM, Grigoryan G, Allen KN, Imperiali B, Keating AE, Structure. 2005 Feb;13(2):225-34. PMID:15698566

Page seeded by OCA on Tue Jul 29 15:20:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xof"
Personal tools