2gdc

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{{STRUCTURE_2gdc| PDB=2gdc | SCENE= }}
{{STRUCTURE_2gdc| PDB=2gdc | SCENE= }}
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'''Structure of Vinculin VD1 / IpaA560-633 complex'''
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===Structure of Vinculin VD1 / IpaA560-633 complex===
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==Overview==
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Invasion of epithelial cells by Shigella flexneri is characterized by cytoskeletal rearrangements of the host cell membrane, promoting internalization of the bacterium. The bacterial effector IpaA is injected into the epithelial cell by a type III secretion apparatus and recruits vinculin to regulate actin polymerization at the site of entry. We analysed the complex formed between a carboxy-terminal fragment of IpaA (IpaA(560-633)) and the vinculin D1 domain (VD1), both in crystals and in solution. We present evidence that IpaA(560-633) has two alpha-helical vinculin-binding sites that simultaneously bind two VD1 molecules. The interaction of IpaA(560-633) with VD1 is highly similar to the interaction of the endogenous, eukaryotic proteins talin and alpha-actinin with VD1, showing that Shigella uses a structural mimicry strategy to activate vinculin.
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{{ABSTRACT_PUBMED_16826238}}
==About this Structure==
==About this Structure==
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[[Category: Ipaa/vinculin complex]]
[[Category: Ipaa/vinculin complex]]
[[Category: Shigella flexneri]]
[[Category: Shigella flexneri]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:58:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:24:12 2008''

Revision as of 12:24, 29 July 2008

Image:2gdc.png

Template:STRUCTURE 2gdc

Structure of Vinculin VD1 / IpaA560-633 complex

Template:ABSTRACT PUBMED 16826238

About this Structure

2GDC is a Protein complex structure of sequences from Gallus gallus and Shigella flexneri. Full crystallographic information is available from OCA.

Reference

Structural mimicry for vinculin activation by IpaA, a virulence factor of Shigella flexneri., Hamiaux C, van Eerde A, Parsot C, Broos J, Dijkstra BW, EMBO Rep. 2006 Aug;7(8):794-9. Epub 2006 Jul 7. PMID:16826238

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