2i2r

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{{Seed}}
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{{STRUCTURE_2i2r| PDB=2i2r | SCENE= }}
{{STRUCTURE_2i2r| PDB=2i2r | SCENE= }}
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'''Crystal structure of the KChIP1/Kv4.3 T1 complex'''
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===Crystal structure of the KChIP1/Kv4.3 T1 complex===
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==Overview==
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Brain I(A) and cardiac I(to) currents arise from complexes containing Kv4 voltage-gated potassium channels and cytoplasmic calcium-sensor proteins (KChIPs). Here, we present X-ray crystallographic and small-angle X-ray scattering data that show that the KChIP1-Kv4.3 N-terminal cytoplasmic domain complex is a cross-shaped octamer bearing two principal interaction sites. Site 1 comprises interactions between a unique Kv4 channel N-terminal hydrophobic segment and a hydrophobic pocket formed by displacement of the KChIP H10 helix. Site 2 comprises interactions between a T1 assembly domain loop and the KChIP H2 helix. Functional and biochemical studies indicate that site 1 influences channel trafficking, whereas site 2 affects channel gating, and that calcium binding is intimately linked to KChIP folding and complex formation. Together, the data resolve how Kv4 channels and KChIPs interact and provide a framework for understanding how KChIPs modulate Kv4 function.
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(as it appears on PubMed at http://www.pubmed.gov), where 17057713 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17057713}}
==About this Structure==
==About this Structure==
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[[Category: Ncs protein]]
[[Category: Ncs protein]]
[[Category: Potassium channel]]
[[Category: Potassium channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:00:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:27:03 2008''

Revision as of 12:27, 29 July 2008

Image:2i2r.png

Template:STRUCTURE 2i2r

Crystal structure of the KChIP1/Kv4.3 T1 complex

Template:ABSTRACT PUBMED 17057713

About this Structure

2I2R is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer., Pioletti M, Findeisen F, Hura GL, Minor DL Jr, Nat Struct Mol Biol. 2006 Nov;13(11):987-95. Epub 2006 Oct 22. PMID:17057713

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