1ojg

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[[Image:1ojg.jpg|left|200px]]
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{{Seed}}
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[[Image:1ojg.png|left|200px]]
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{{STRUCTURE_1ojg| PDB=1ojg | SCENE= }}
{{STRUCTURE_1ojg| PDB=1ojg | SCENE= }}
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'''SENSORY DOMAIN OF THE MEMBRANEOUS TWO-COMPONENT FUMARATE SENSOR DCUS OF E. COLI'''
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===SENSORY DOMAIN OF THE MEMBRANEOUS TWO-COMPONENT FUMARATE SENSOR DCUS OF E. COLI===
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==Overview==
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The structure of the water-soluble, periplasmic domain of the fumarate sensor DcuS (DcuS-pd) has been determined by NMR spectroscopy in solution. DcuS is a prototype for a sensory histidine kinase with transmembrane signal transfer. DcuS belongs to the CitA family of sensors that are specific for sensing di- and tricarboxylates. The periplasmic domain is folded autonomously and shows helices at the N and the C terminus, suggesting direct linking or connection to helices in the two transmembrane regions. The structure constitutes a novel fold. The nearest structural neighbor is the Per-Arnt-Sim domain of the photoactive yellow protein that binds small molecules covalently. Residues Arg107, His110, and Arg147 are essential for fumarate sensing and are found clustered together. The structure constitutes the first periplasmic domain of a two component sensory system and is distinctly different from the aspartate sensory domain of the Tar chemotaxis sensor.
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(as it appears on PubMed at http://www.pubmed.gov), where 12907689 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12907689}}
==About this Structure==
==About this Structure==
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1OJG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OJG OCA].
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1OJG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OJG OCA].
==Reference==
==Reference==
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[[Category: Histidine kinase]]
[[Category: Histidine kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:55:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:28:32 2008''

Revision as of 12:28, 29 July 2008

Image:1ojg.png

Template:STRUCTURE 1ojg

SENSORY DOMAIN OF THE MEMBRANEOUS TWO-COMPONENT FUMARATE SENSOR DCUS OF E. COLI

Template:ABSTRACT PUBMED 12907689

About this Structure

1OJG is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli., Pappalardo L, Janausch IG, Vijayan V, Zientz E, Junker J, Peti W, Zweckstetter M, Unden G, Griesinger C, J Biol Chem. 2003 Oct 3;278(40):39185-8. Epub 2003 Aug 7. PMID:12907689

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