333d

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{{Seed}}
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{{STRUCTURE_333d| PDB=333d | SCENE= }}
{{STRUCTURE_333d| PDB=333d | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES'''
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===THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES===
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==Overview==
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The X-ray crystallographic structure of the RNA duplex [r(CGCAIGCG)]2 has been refined to 2.5 A. It shows a symmetric internal loop of two non-Watson-Crick base pairs which form in the middle of the duplex. The tandem A-I/I-A pairs are related by a crystallographic two-fold axis. Both A(anti)-I(anti) mismatches are in a head-to-head conformation forming hydrogen bonds using the Watson-Crick positions. The octamer duplexes stack above one another in the cell forming a pseudo-infinite helix throughout the crystal. A hydrated calcium ion bridges between the 3'-terminal of one molecule and the backbone of another. The tandem A-I mismatches are incorporated with only minor distortion to the backbone. This is in contrast to the large helical perturbations often produced by sheared G-A pairs in RNA oligonucleotides.
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The line below this paragraph, {{ABSTRACT_PUBMED_9321667}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9321667 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9321667}}
==About this Structure==
==About this Structure==
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[[Category: Internal loop]]
[[Category: Internal loop]]
[[Category: Mismatched]]
[[Category: Mismatched]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:16:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:29:57 2008''

Revision as of 12:30, 29 July 2008

Image:333d.png

Template:STRUCTURE 333d

THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES

Template:ABSTRACT PUBMED 9321667

About this Structure

Full crystallographic information is available from OCA.

Reference

The crystal structure of an RNA oligomer incorporating tandem adenosine-inosine mismatches., Carter RJ, Baeyens KJ, SantaLucia J, Turner DH, Holbrook SR, Nucleic Acids Res. 1997 Oct 15;25(20):4117-22. PMID:9321667

Page seeded by OCA on Tue Jul 29 15:29:57 2008

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