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1jzp

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[[Image:1jzp.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1jzp| PDB=1jzp | SCENE= }}
{{STRUCTURE_1jzp| PDB=1jzp | SCENE= }}
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'''Modified Peptide A (D18-A1) of the Rabbit Skeletal Dihydropyridine Receptor'''
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===Modified Peptide A (D18-A1) of the Rabbit Skeletal Dihydropyridine Receptor===
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==Overview==
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An alpha-helical II-III loop segment of the dihydropyridine receptor activates the ryanodine receptor calcium-release channel. We describe a novel manipulation in which this agonist's activity is increased by modifying its surface structure to resemble that of a toxin molecule. In a unique system, native beta-sheet scorpion toxins have been reported to activate skeletal muscle ryanodine receptor calcium channels with high affinity by binding to the same site as the lower-affinity alpha-helical dihydropyridine receptor segment. We increased the alignment of basic residues in the alpha-helical peptide to mimic the spatial orientation of active residues in the scorpion toxin, with a consequent 2-20-fold increase in the activity of the alpha-helical peptide. We hypothesized that, like the native peptide, the modified peptide and the scorpion toxin may bind to a common site. This was supported by (i) similar changes in ryanodine receptor channel gating induced by the native or modified alpha-helical peptide and the beta-sheet toxin, a 10-100-fold reduction in channel closed time, with a &lt; or = 2-fold increase in open dwell time and (ii) a failure of the toxin to further activate channels activated by the peptides. These results suggest that diverse structural scaffolds can present similar conformational surface properties to target common receptor sites.
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The line below this paragraph, {{ABSTRACT_PUBMED_12429019}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12429019 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12429019}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZP OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZP OCA].
==Reference==
==Reference==
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[[Category: D-isomer]]
[[Category: D-isomer]]
[[Category: Dhpr]]
[[Category: Dhpr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:07:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:33:55 2008''

Revision as of 12:33, 29 July 2008

Image:1jzp.png

Template:STRUCTURE 1jzp

Modified Peptide A (D18-A1) of the Rabbit Skeletal Dihydropyridine Receptor

Template:ABSTRACT PUBMED 12429019

About this Structure

Full experimental information is available from OCA.

Reference

The three-dimensional structural surface of two beta-sheet scorpion toxins mimics that of an alpha-helical dihydropyridine receptor segment., Green D, Pace S, Curtis SM, Sakowska M, Lamb GD, Dulhunty AF, Casarotto MG, Biochem J. 2003 Mar 1;370(Pt 2):517-27. PMID:12429019

Page seeded by OCA on Tue Jul 29 15:33:55 2008

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