2erm

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[[Image:2erm.jpg|left|200px]]
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{{Seed}}
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[[Image:2erm.png|left|200px]]
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{{STRUCTURE_2erm| PDB=2erm | SCENE= }}
{{STRUCTURE_2erm| PDB=2erm | SCENE= }}
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'''Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue'''
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===Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue===
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==Overview==
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The 3D structure of a complex formed by the acidic fibroblast growth factor (FGF-1) and a specifically designed synthetic heparin hexasaccharide has been determined by NMR spectroscopy. This hexasaccharide can substitute natural heparins in FGF-1 mitogenesis assays, in spite of not inducing any apparent dimerization of the growth factor. The use of this well defined synthetic heparin analogue has allowed us to perform a detailed NMR structural analysis of the heparin-FGF interaction, overcoming the limitations of NMR to deal with the high molecular mass and heterogeneity of the FGF-1 oligomers formed in the presence of natural heparin fragments. Our results confirm that glycosaminoglycans induced FGF-1 dimerization either in a cis or trans disposition with respect to the heparin chain is not an absolute requirement for biological activity.
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The line below this paragraph, {{ABSTRACT_PUBMED_16995857}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16995857 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16995857}}
==About this Structure==
==About this Structure==
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2ERM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERM OCA].
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2ERM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERM OCA].
==Reference==
==Reference==
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[[Category: Heparin-like hexasaccharide]]
[[Category: Heparin-like hexasaccharide]]
[[Category: Protein-carbohydrate complex]]
[[Category: Protein-carbohydrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:02:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:39:00 2008''

Revision as of 12:39, 29 July 2008

Image:2erm.png

Template:STRUCTURE 2erm

Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue

Template:ABSTRACT PUBMED 16995857

About this Structure

2ERM is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue., Canales A, Lozano R, Lopez-Mendez B, Angulo J, Ojeda R, Nieto PM, Martin-Lomas M, Gimenez-Gallego G, Jimenez-Barbero J, FEBS J. 2006 Oct;273(20):4716-27. Epub 2006 Sep 21. PMID:16995857

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