1od5

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{{Seed}}
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{{STRUCTURE_1od5| PDB=1od5 | SCENE= }}
{{STRUCTURE_1od5| PDB=1od5 | SCENE= }}
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'''CRYSTAL STRUCTURE OF GLYCININ A3B4 SUBUNIT HOMOHEXAMER'''
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===CRYSTAL STRUCTURE OF GLYCININ A3B4 SUBUNIT HOMOHEXAMER===
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==Overview==
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Most plant seeds contain 11S globulins as major storage proteins for their nutrition. Soybean glycinin belongs to the 11S globulin family and consists of five kinds of subunits. We determined the crystal structure of a homohexamer of the glycinin A3B4 subunit at 2.1-A resolution. The crystal structure shows that the hexamer has 32-point group symmetry formed by face-to-face stacking of two trimers. The interface buries the highly conserved interchain disulfide. Based on the structure, we propose that an ingenious face-to-face mechanism controls the hexamer formation of the 11S globulin by movement of a mobile disordered region to the side of the trimer after posttranslational processing. Electrostatic analysis of the faces suggests that the interchain disulfide-containing face has high positive potential at acidic pH, which induces dissociation of the hexamer into trimers that may be susceptible to proteinases after seed imbibition. This dissociation might result in the degradation and mobilization of 11S globulins as storage proteins in embryos during germination and seedling growth.
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(as it appears on PubMed at http://www.pubmed.gov), where 12771376 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12771376}}
==About this Structure==
==About this Structure==
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[[Category: Glycinin]]
[[Category: Glycinin]]
[[Category: Soybean]]
[[Category: Soybean]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:41:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:40:01 2008''

Revision as of 12:40, 29 July 2008

Template:STRUCTURE 1od5

CRYSTAL STRUCTURE OF GLYCININ A3B4 SUBUNIT HOMOHEXAMER

Template:ABSTRACT PUBMED 12771376

About this Structure

1OD5 is a Single protein structure of sequence from Glycine max. Full crystallographic information is available from OCA.

Reference

Crystal structure of soybean 11S globulin: glycinin A3B4 homohexamer., Adachi M, Kanamori J, Masuda T, Yagasaki K, Kitamura K, Mikami B, Utsumi S, Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7395-400. Epub 2003 May 27. PMID:12771376

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