2f6a

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{{STRUCTURE_2f6a| PDB=2f6a | SCENE= }}
{{STRUCTURE_2f6a| PDB=2f6a | SCENE= }}
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'''Collagen Adhesin and Collagen Complex Structure'''
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===Collagen Adhesin and Collagen Complex Structure===
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==Overview==
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The structural basis for the association of eukaryotic and prokaryotic protein receptors and their triple-helical collagen ligand remains poorly understood. Here, we present the crystal structures of a high affinity subsegment of the Staphylococcus aureus collagen-binding CNA as an apo-protein and in complex with a synthetic collagen-like triple helical peptide. The apo-protein structure is composed of two subdomains (N1 and N2), each adopting a variant IgG-fold, and a long linker that connects N1 and N2. The structure is stabilized by hydrophobic inter-domain interactions and by the N2 C-terminal extension that complements a beta-sheet on N1. In the ligand complex, the collagen-like peptide penetrates through a spherical hole formed by the two subdomains and the N1-N2 linker. Based on these two structures we propose a dynamic, multistep binding model, called the 'Collagen Hug' that is uniquely designed to allow multidomain collagen binding proteins to bind their extended rope-like ligand.
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{{ABSTRACT_PUBMED_16362049}}
==About this Structure==
==About this Structure==
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[[Category: Ecm]]
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[[Category: Mscramm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:30:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:42:31 2008''

Revision as of 12:42, 29 July 2008

Image:2f6a.png

Template:STRUCTURE 2f6a

Collagen Adhesin and Collagen Complex Structure

Template:ABSTRACT PUBMED 16362049

About this Structure

2F6A is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

A 'Collagen Hug' model for Staphylococcus aureus CNA binding to collagen., Zong Y, Xu Y, Liang X, Keene DR, Hook A, Gurusiddappa S, Hook M, Narayana SV, EMBO J. 2005 Dec 21;24(24):4224-36. Epub 2005 Dec 15. PMID:16362049

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