This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1p8v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1p8v.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1p8v.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1p8v| PDB=1p8v | SCENE= }}
{{STRUCTURE_1p8v| PDB=1p8v | SCENE= }}
-
'''CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A'''
+
===CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A===
-
==Overview==
+
<!--
-
Direct interaction between platelet receptor glycoprotein Ibalpha (GpIbalpha) and thrombin is required for platelet aggregation and activation at sites of vascular injury. Abnormal GpIbalpha-thrombin binding is associated with many pathological conditions,including occlusive arterial thrombosis and bleeding disorders. The crystal structure of the GpIbalpha-thrombin complex at 2.6 angstrom resolution reveals simultaneous interactions of GpIbalpha with exosite I of one thrombin molecule,and with exosite II of a second thrombin molecule. In the crystal lattice,the periodic arrangement of GpIbalpha-thrombin complexes mirrors a scaffold that could serve as a driving force for tight platelet adhesion. The details of these interactions reconcile GpIbalpha-thrombin binding modes that are presently controversial,highlighting two distinct interfaces that are potential targets for development of novel antithrombotic drugs.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12855811}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12855811 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12855811}}
==Disease==
==Disease==
Line 33: Line 37:
[[Category: Leucine rich repeat domain]]
[[Category: Leucine rich repeat domain]]
[[Category: Platelet glycoprotein receptor]]
[[Category: Platelet glycoprotein receptor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:49:52 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:51:12 2008''

Revision as of 12:51, 29 July 2008

Image:1p8v.png

Template:STRUCTURE 1p8v

Contents

CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A

Template:ABSTRACT PUBMED 12855811

Disease

Known disease associated with this structure: Bernard-Soulier syndrome, type A OMIM:[606672], von Willebrand disease, platelet-type OMIM:[606672], Nonarteritic anterior ischemic optic neuropathy, susceptibility to OMIM:[606672]

About this Structure

1P8V is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation., Dumas JJ, Kumar R, Seehra J, Somers WS, Mosyak L, Science. 2003 Jul 11;301(5630):222-6. PMID:12855811

Page seeded by OCA on Tue Jul 29 15:51:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1p8v"
Personal tools