2f2l

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{{STRUCTURE_2f2l| PDB=2f2l | SCENE= }}
{{STRUCTURE_2f2l| PDB=2f2l | SCENE= }}
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'''Crystal structure of tracheal cytotoxin (TCT) bound to the ectodomain complex of peptidoglycan recognition proteins LCa (PGRP-LCa) and LCx (PGRP-LCx)'''
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===Crystal structure of tracheal cytotoxin (TCT) bound to the ectodomain complex of peptidoglycan recognition proteins LCa (PGRP-LCa) and LCx (PGRP-LCx)===
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==Overview==
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Tracheal cytotoxin (TCT), a naturally occurring fragment of Gram-negative peptidoglycan, is a potent elicitor of innate immune responses in Drosophila. It induces the heterodimerization of its recognition receptors, the peptidoglycan recognition proteins (PGRPs) LCa and LCx, which activates the immune deficiency pathway. The crystal structure at 2.1 angstrom resolution of TCT in complex with the ectodomains of PGRP-LCa and PGRP-LCx shows that TCT is bound to and presented by the LCx ectodomain for recognition by the LCa ectodomain; the latter lacks a canonical peptidoglycan-docking groove conserved in other PGRPs. The interface, revealed in atomic detail, between TCT and the receptor complex highlights the importance of the anhydro-containing disaccharide in bridging the two ectodomains together and the critical role of diaminopimelic acid as the specificity determinant for PGRP interaction.
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(as it appears on PubMed at http://www.pubmed.gov), where 16556841 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16556841}}
==About this Structure==
==About this Structure==
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[[Category: Deisenhofer, J.]]
[[Category: Deisenhofer, J.]]
[[Category: Protein-peptidoglycan complex]]
[[Category: Protein-peptidoglycan complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:53:11 2008''

Revision as of 12:53, 29 July 2008

Image:2f2l.png

Template:STRUCTURE 2f2l

Crystal structure of tracheal cytotoxin (TCT) bound to the ectodomain complex of peptidoglycan recognition proteins LCa (PGRP-LCa) and LCx (PGRP-LCx)

Template:ABSTRACT PUBMED 16556841

About this Structure

2F2L is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor., Chang CI, Chelliah Y, Borek D, Mengin-Lecreulx D, Deisenhofer J, Science. 2006 Mar 24;311(5768):1761-4. PMID:16556841

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